Plenary & Platform Session Listing

PLENARY/PLATFORM SESSIONS LISTING

Wednesday, April 3   7:00 PM–9:00 PM

Opening General Session

Co-Moderators: Richard Mann, Columbia University, New York and Kristin Scott, University of California, Berkeley

Room: Marriott Ballroom Salons 1-3, Lobby Level

Presentations:

7:00 pm   Welcome and Opening Remarks. Richard Mann. Columbia University, New York.

7:15 pm   GSA Welcome and Update. Adam Fagen. Genetics Society of America, Bethesda, Maryland.

7:25 pm   Larry Sandler Award Presentation. Ken Irvine. Rutgers University, Waksman Institute, Piscataway, New Jersey.

7:30 pm   Larry Sandler Lecture.

8:00 pm   Jules Hoffmann Introduction. Kristin Scott. University of California, Berkeley.

8:05 pm   Innate Immunity : From Flies to Humans. Jules A. Hoffmann. IBMC, University of Strasbourg, Strasbourg, France.

8:50 pm   Presentation of George W. Beadle Award to R. Scott Hawley, Stowers Institute for Medical Research. Adam Fagen. Genetics Society of America, Bethesda, MD.

Thursday, April 4   8:30 AM–12:30 PM

Plenary Session

Moderator: David Stern, Janelia Farm Research Campus, Arlington, Virginia

Room: Marriott Ballroom Salons 1-3, Lobby Level

Presentations:

8:30 am   Image Award Presentation. David Bilder. University of California, Berkeley.

8:35 am   Molecular Mechanisms of Axon Degeneration. Marc R. Freeman. Dept Neurobiology, Univ Massachusetts Med Sch/HHMI, Worcester, MA.

9:05 am   Genetic Approaches to Dissecting Neural Computation in the Visual System. Tom Clandinin. Dept of Neurobiology, Stanford University, Stanford, CA.

9:35 am   The Genomics of Speciation and Pattern Evolution in (butter)flies. Chris Jiggins. Dept Zoology, University of Cambridge, Cambridge, United Kingdom.

10:05 am - Break

10:30 am   Creating Gradients by Morphogen Shuttling. Naama Barkai. Weizman Institute, Rehovot, Israel.

11:00 am   Maintenance of Niche Function and Tissue Homeostasis During Aging. Leanne Jones. Laboratory of Genetics, Salk Inst, La Jolla, CA.

11:30 am   Histone Genetics in Drosophila. Jürg Müller. Max-Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Bavaria, Germany.

12:00 noon   Presentation of FASEB Excellence in Science Award to Terry Orr-Weaver. Judith Bond. President, FASEB, Bethesda, MD.

12:05 pm   Diamonds in the Rough: Finding Paradigms in Drosophila Developmental Strategies. Terry Orr-Weaver. Whitehead Institute, MIT, Cambridge Massachusetts.

Thursday, April 4   4:30 PM–6:30 PM

Techniques and Functional Genomics/Systems Biology

Co-Moderators: Tzumin Lee, Janelia Farms Research Institute, Arlington, Virginia and Ward Odenwald, NIH, Bethesda, Maryland and Thomas Gregor, Princeton University, New Jersey and Richard Carthew, Northwestern University, Evanston, Illinois

Room: Marriott Ballroom Salon 1, Lobby Level

1 - 4:30
A new frontier for the Duplication Consortium: retrofitted BACs that span very large Drosophila genes and the 4th chromosome. Koen Venken^1,2, Stacy Holtzman³, Soo Park⁴, Joe Carlson⁴, Roger Hoskins⁴, Hugo Bellen¹, Thom Kaufman³. 1) Molecular and Human Genetics, BCM, Houston, TX; 2) Biochemistry and Molecular Biology, BCM, Houston, TX; 3) Biology, IA, Bloomington, IN; 4) Life Sciences Division, LBNL, Berkeley, CA.

2 - 4:45
Captured segment exchange: A strategy for custom engineering large genomic regions in Drosophila melanogaster. Jack R. Bateman, Michael F. Palopoli, Sarah T. Dale, Jennifer E. Stauffer, Anita L. Shah, Justine E. Johnson, Conor W. Walsh, Hanna Flaten, Christine M. Parsons. Biology Department, Bowdoin College, Brunswick, ME.

3 - 5:00
Gene Targeting with TALENs in Drosophila. Dana Carroll¹, Kelly J. Beumer¹, Jonathan K. Trautman¹, Michelle Christian², Timothy J. Dahlem³, Cathleen Lake⁴, R. Scott Hawley⁴, David J. Grunwald³, Daniel F. Voytas². 1) Dept Biochem, Univ Utah Sch Med, Salt Lake City, UT; 2) Dept Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN; 3) Dept Human Genetics, Univ Utah Sch Med, Salt Lake City, UT; 4) Stowers Institute, Kansas City, MO.

4 - 5:15
Pyrimidine salvaging enzyme UPRTase is active in Drosophila and limits the specificity of tissue specific RNA isolation by 4TU tagging. Arpan Ghosh, MaryJane Shimmel, Emma Leof, Michael O'Connor. Gen Cell & Development, Univ Minnesota Twin Cities, Minneapolis, MN.

5 - 5:30
Sequencing mRNA from cryo-sliced Drosophila embryos to determine genome-wide spatial patterns of gene expression. Peter A. Combs¹, Michael B. Eisen^2,3. 1) Biophysics Graduate Group, University of California, Berkeley, CA; 2) Department of Molecular and Cell Biology, University of California, Berkeley, CA; 3) Howard Hughes Medical Institute, University of California, Berkeley, CA.

6 - 5:45
Mechanical aspects of fruit fly gastrulation. Konstantin Doubrovinski^1,2, Bing He¹, Oleg Polyakov¹, Eric Wieschaus^1,2. 1) Princeton University, Princeton, NJ; 2) Howard Hughes Medical Institute.

7 - 6:00
Genomic and transcriptomic analysis of diapause—an important life history trait in Drosophila melanogaster. Xiaqing Zhao¹, Alan Bergland², Dmitri Petrov², Paul Schmidt¹. 1) Dept. of Biology, University of Pennsylvania, Philadelphia, PA; 2) Dept. of Biology, Stanford University, Stanford, CA.

8 - 6:15
Solving navigational circuits in the Drosophila larva. Marc Gershow¹, Mason Klein¹, Marta Zlatic², Matthew Berck¹, Elizabeth Kane¹, Bruno Afonso¹, Aravinthan Samuel¹. 1) Center for Brain Science, Harvard University, Cambridge, MA; 2) HHMI Janelia Farm, Ashburn, VA.

Thursday, April 4   4:30 PM–6:30 PM

Cell Division and Growth Control

Co-Moderators: Robert Duronio, University of North Carolina, Chapel Hill and Pat O'Farrell, University of California, San Francisco

Room: Marriott Ballroom Salon 2, Lobby Level

9 - 4:30
Proper chromosome segregation and spindle assembly require both kinetochore and central spindle components in Drosophila oocytes. Sarah J. Radford, Kim S. McKim. Waksman Institute, Rutgers University, Piscataway, NJ.

10 - 4:45
The oocyte-to-embryo transition requires APC/C mediated destruction of Matrimony, a POLO kinase inhibitor. Zachary J. Whitfield¹, Jennifer Chisholm², R. Scott Hawley², Terry L. Orr-Weaver¹. 1) Whitehead Institute for Biomedical Research, MIT, Cambridge, MA; 2) Stowers Institute for Medical Research, Kansas City, MO.

11 - 5:00
Regulation of the asymmetric centrosome maturation cycle in neural stem cells. Dorothy A. Lerit, Nasser M. Rusan. Cell Biology and Physiology Center, NHLBI, National Institutes of Health, Bethesda, MD.

12 - 5:15
The role of corp in apoptosis following DNA damage. Riddhita Chakraborty, Simon W. Titen, Kent G. Golic. Department of Biology, University of Utah, Salt Lake City, UT.

13 - 5:30
Tissue repair through cell competition and compensatory cellular hypertrophy in postmitotic epithelia. Yoichiro Tamori, Wu-Min Deng. Biological Science, Florida State University, Tallahassee, FL.

14 - 5:45
The transcriptional response to tumorigenic polarity loss. Brandon D. Bunker¹, Anne-Kathrin Classen², Tittu T. Nellimoottil³, David Bilder¹. 1) Molecular and Cell Biology, University of California-Berkeley, Berkeley, CA 94720; 2) Biology II, Ludwig-Maximilians-University, Munich, D-82152 Germany; 3) Biological Sciences, University of Southern California, Los Angeles, CA 90033.

15 - 6:00
Cell competition as a mechanism that can promote tumour growth through JNK activation. Luna L. Ballesteros-Arias, Verónica Saavedra, Ginés Morata. Centro de Biología Molecular Severo Ochoa, Madrid, Spain.

16 - 6:15
Identification and verification of genes involved in apoptosis-induced proliferation in Drosophila. Yun Fan^1,2, Andreas Bergmann². 1) School of Biosciences, University of Birmingham, Birmingham, United Kingdom; 2) Cancer Biology, UMass Medical School, Worcester, United States.

Thursday, April 4   4:30 PM–6:30 PM

Physiology and Aging

Co-Moderators: Scott Pletcher, University of Michigan, Ann Arbor and Heinrich Jasper, Buck Institute, Novato, California

Room: Marriott Ballroom Salon 3, Lobby Level

17 - 4:30
HIF- and non-HIF-Regulated Hypoxic Responses Require the Estrogen-Related Receptor in Drosophila. Keith D. Baker¹, Yan Li¹, Divya Padmanabha¹, Luciana B. Gentile¹, Catherine I. Dumur², Robert B. Beckstead³. 1) Biochemistry and Molecular Biology, VCU School of Medicine, Richmond, VA; 2) Pathology, VCU School of Medicine, Richmond, VA; 3) Poultry Science, University of Georgia, Athens, GA.

18 - 4:45
Loss of the Drosophila nuclear receptor dHNF4 recapitulates Maturity Onset Diabetes of the Young 1. William E. Barry, Carl S. Thummel. Department of Human Genetics, University of Utah, Salt Lake City, UT.

19 - 5:00
Central regulation of lipid metabolism and starvation response by a histone acetyl-transferase. Nina Moderau, Ingo Zinke, Michael J. Pankratz. Molecular Brain Physiology and Behavior, LIMES Institute, University of Bonn, 53115 Bonn, Germany.

20 - 5:15
Control of ovarian stem cells by adipocytes in response to diet. Alissa Armstrong¹, Leesa Sampson¹, Kaitlin Laws¹, Robert Cole², Daniela Drummond-Barbosa¹. 1) Biochemistry and Molecular Biology, JHU School of Public Health, Baltimore, MD; 2) Mass Spectrometry and Proteomics Facility, JHU School of Medicine, Baltimore, MD.

21 - 5:30
Social interactions drive organism non-autonomous regulation of lifespan through pheromone perception. Christi Gendron¹, Tsung-Han Kuo², Zachary Harvanek¹, Ingrid Hansen², Scott Pletcher^1,2. 1) Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI; 2) Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.

22 - 5:45
A Role for Drosophila p38 MAP Kinase in Protein Homeostasis. Alysia D. Vrailas-Mortimer^1,2, Amelia M. Burch¹, Subhabrata Sanyal^1,2,3. 1) Cell Biology, Emory University, Atlanta, GA; 2) Center for Behavioral Neuroscience, Atlanta, GA; 3) Center for Neurodegenerative Disease, Emory University, Atlanta, GA.

23 - 6:00
In vivo interaction proteomics reveal a novel role of p38MAPK in controlling proteostasis in ageing Drosophila muscle. Vladimir Belozerov^1,2, Anne-Claude Gingras², Helen McNeill², John McDermott¹. 1) Department of Biology, York University, Toronto, ON, Canada; 2) Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.

24 - 6:15
A metabolic adaptation in muscle mediates the protective effects of dietary restriction in Drosophila. Subhash D. Katewa, Kazutaka Akagi, Matthew J. Laye, Pankaj Kapahi. Buck Institute for Research on Aging, Novato, CA.

Friday, April 5   8:30 AM–10:15 AM

Evolution and Quantitative Genetics I

Co-Moderators: Peter Andolfatto, Princeton University, New Jersey and Harmit Malik, Fred Hutchinson Cancer Institute, Seattle, Washington

Room: Marriott Ballroom Salon 1, Lobby Level

25 - 8:30
Recent and strong adaptation in Drosophila melanogaster is driven primarily by soft selective sweeps. Nandita Garud, Philipp Messer, Erkan Buzbas, Dmitri Petrov. Stanford University, Stanford, CA.

26 - 8:45
Population and metabolic genomics of five geographically dispersed fully-sequenced population samples of Drosophila melanogaster. Andrew G. Clark¹, J. Roman Arguello¹, Margarida Cardoso Moreira¹, Jian Lu¹, Cornelia J. Scheitz¹, Anthony J. Greenberg¹, Sean R. Hackett^1,2, Julien F. Ayroles^1,3, Srikanth Gottipati¹, Lawrence G. Harshman⁴, Jennifer K. Grenier¹. 1) Dept Molec Biol & Gen, Cornell Univ, Ithaca, NY; 2) Grad Program Quant and Comp Biology, Princeton Univ, Princeton, NJ; 3) Dept of OEB, Harvard Univ, Cambridge MA; 4) School of Biol Sciences, Univ Nebraska, Lincoln, NE.

27 - 9:00
Parallel selection on copy-number variants across continents and species in Drosophila. Daniel R. Schrider^1,2, Matthew W. Hahn^1,2, David J. Begun³. 1) Department of Biology. Indiana Univesity, Bloomington, IN; 2) School of Informatics and Computing. Indiana Univesity, Bloomington, IN; 3) Department of Evolution and Ecology. University of California. Davis, CA.

28 - 9:15
Interpreting faster-X evolution in light of expression breadth and adaptation. Richard Meisel. Cornell University.

29 - 9:30
Neofunctionalization of young duplicate genes in Drosophila. Raquel Assis, Doris Bachtrog. Integrative Biology, University of California, Berkeley, Berkeley, CA.

30 - 9:45
Signatures of correlated evolution predict new members of a protein network required for Drosophila female post-mating responses. Geoffrey D. Findlay¹, Nathaniel L. Clark^1,2, Jessica L. Sitnik¹, Charles F. Aquadro¹, Mariana F. Wolfner¹. 1) Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY; 2) Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA.

31 - 10:00
The role of the Drosophila meiotic MCM proteins in crossover formation. Kathryn P. Kohl, Corbin D. Jones, Jeff Sekelsky. University of North Carolina at Chapel Hill, Chapel Hill, NC.

Friday, April 5   8:30 AM–10:15 AM

Cell Biology and Signal Transduction I

Co-Moderators: Helen McNeil, Mount Sinai Hospital, Toronto, Canada and Jin Jiang, UTSW, Dallas, Texas

Room: Marriott Ballroom Salon 2, Lobby Level

32 - 8:30
Contact-mediated long distance signaling by Drosophila cytonemes. Sougata Roy, Thomas B. Kornberg. Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA.

33 - 8:45
Ubquitination of Costal 2 by the Ubr3 E3 ligase is required for proper Hedgehog signaling. Tongchao Li¹, Nikos Giagtzoglou², Junkai Fan⁷, Jianhang Jia⁷, Sinya Yamamoto¹, Wu-Lin Charng¹, Manish Jaiwal², Hector Sandoval², Vafa Bayat^1,5, Bo Xiong¹, Ke Zhang³, Gabriela David¹, Andy Groves^1,2,4, Hugo Bellen^1,2,3,4,6. 1) Program in Developmental Biology; 2) Department of Molecular and Human Genetics; 3) Program in Structural and Computational Biology & Molecular Biophysics; 4) Department of Neuroscience; 5) Medical Scientist Training Program; 6) Howard Hughes Medical Institute, Neurological Research Institute at Baylor College of Medicine, Houston, Texas; 7) Markey Cancer Center, University of Kentucky, Lexington, KY.

34 - 9:00
Contribution of Ihog and Boi to the Hedgehog receptor in Drosophila. Darius Camp^1,2, Haitian He¹, Don van Meyel¹, Frédéric Charron². 1) Centre for Research in Neuroscience, McGill University, Montreal, Quebec, Canada; 2) Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada.

35 - 9:15
The Formin Frl functions in Planar Cell Polarity Signaling in Drosophila. Andreas Jenny¹, Saw-Myat Maung¹, Gretchen Dollar¹, Cathie Pfleger². 1) Dept Molec & Dev Biol, Albert Einstein Col Med, Bronx, NY; 2) Department of Oncological Sciences Mount Sinai School of Medicine, New York, NY.

36 - 9:30
Frizzled induced Van Gogh phosphorylation regulates PCP signaling. Lindsay Kelly, Marek Mlodzik. Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY.

37 - 9:45
CG9723 is required for spermatogenesis in Drosophila. Robyn Rosenfeld^1,2, Helen McNeill^1,2. 1) Samuel Lunenfeld Research Institute, Mount Sinai hospital, Toronto, ON, Canada; 2) Molecuar Genetics, University of Toronto, Toronto, ON, Canada.

38 - 10:00
Exosomes, secreted from secondary cells of the male accessory glands, fuse with sperm and female epithelia to modulate reproductive function. Laura Corrigan¹, Shih-Jung Fan¹, Carina Gandy¹, Aaron Leiblich¹, Rachel Patel¹, Siamak Redhai¹, John Morris¹, Freddie Hamdy², Clive Wilson¹. 1) Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom; 2) Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

Friday, April 5   8:30 AM–10:15 AM

Immunity and Pathogenesis

Co-Moderators: Mimi Shirasu-Hiza, Columbia University, New York and Horatio Frydman, Boston University, Massachusetts

Room: Marriott Ballroom Salon 3, Lobby Level

39 - 8:30
Drosophila genome-wide RNAi screen identifies novel genes involved in Sindbis virus entry. Debasis Panda, Patrick Rose, Sheri Hanna, Beth Gold, Sara Cherry. Microbiology, University of Pennsylvania, Philadelphia, PA.

40 - 8:45
TAK1-dependent Ubiquitin Chain Editing Regulates IMD Signaling. Li Chen, Uday Aggarwal, Boae Choi, Neal Silverman. Med/Div Infectious Dis, Univ Massachusetts Med Sch, Worcester, MA.

41 - 9:00
JAK/STAT pathway in autophagic control of intracellular mycobacteria. Claire Péan, Sharon W.S.Tan, Marc Dionne. CMCBI, Kings College London, London, United Kingdom.

42 - 9:15
Vertical transmission of a Drosophila endosymbiont via co-option of the yolk transport and internalization machinery. Jeremy K. Herren, Juan C. Paredes, Fanny Schupfer, Bruno Lemaitre. Global Health Institute, EPFL, Lausanne, Vaud, Switzerland.

43 - 9:30
Intersection of Drosophila innate immunity and epidermal wound response in the serine proteolytic pathway. Michelle T. Juarez, Rachel A. Patterson, William McGinnis. University of California, San Diego, La Jolla, CA.

44 - 9:45
The dynamics of tolerance and resistance in heterogeneous environments. Virginia Howick, Brian Lazzaro. Cornell University, Ithaca, NY.

45 - 10:00
Investigating the Host-Pathogen Interaction: Tolerance in Perspective. Kyung Han Song, David Schneider. Dept of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, CA.

Friday, April 5   10:45 AM–12:30 PM

Evolution and Quantitative Genetics II

Co-Moderators: Peter Andolfatto, Princeton University, New Jersey and Harmit Malik, Fred Hutchinson Cancer Center, Seattle, Washington

Room: Marriott Ballroom Salon 1, Lobby Level

46 - 10:45
Evolutionary change in fatty acid synthase expression underlies ecological divergence and reproductive isolation in a pair of Australian Drosophila species. Henry Chung¹, David Loehlin¹, Kathy Vacarro¹, Heloise Dufour¹, Jocelyn Millar², Sean Carroll¹. 1) HHMI and Laboratory of Molecular Biology, University of Wisconsin, Madison, WI; 2) 2Department of Entomology, University of California, Riverside, CA.

47 - 11:00
Evolution of miR-92a underlies natural variation in the naked valley in Drosophila melanogaster. Saad Arif¹, Sophie Murat², Isabel Almudi¹, Maria Nunes¹, Diane Bortolamiol-Becet³, Naomi McGregor¹, James Currie¹, Matthew Ronshaugen⁴, Elio Sucena⁵, Eric C. Lai³, Christian Schlötterer², Alistair McGregor¹. 1) Oxford Brookes University, Oxford, United Kingdom; 2) Institute for Population Genetics, Vetmeduni Vienna, Vienna, Austria; 3) Sloan-Kettering Institute, New York, NY, USA; 4) Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom; 5) Instituto Gulbenkian de Ciência, Oeiras, Portugal.

48 - 11:15
The power of a multivariate approach to genome-wide association studies. David Houle¹, Jessica Nye^1,2, Eladio Marquez¹, William Pitchers³, Alycia Kowalski³, Ian Dworkin³. 1) Dept Biological Science, Florida State Univ, Tallahassee, FL; 2) Dept. of Genetics, North Carolina State Univ, Raleigh, NC; 3) Dept. of Zoology, Michigan State University, Lansing, MI.

49 - 11:30
The severity of a mitochondrial-nuclear incompatibility depends upon the developmental thermal environment. Kristi L. Montooth, Luke A. Hoekstra, Mohammad A. Siddiq. Dept Biol, Indiana Univ, Bloomington, IN.

50 - 11:45
A Drosophila Model to Investigate Natural Variation Effect in Response to Expression of A Human Misfolded Protein. Bin He¹, Michael Ludwig¹, Soo-Young Park², Pengyao Jiang¹, Cecelia Miles³, Levi Barse¹, Desiree Dickerson¹, Sarah Carl¹, Graeme Bell², Martin Kreitman¹. 1) Department of Ecology & Evolution, The University of Chicago, Chicago, IL; 2) Department of Medicine, The University of Chicago, Chicago, IL; 3) Biology Department, Augustana College, Sioux Falls, SD.

51 - 12:00
From missing genotypes to negative epistasis. Russ Corbett-Detig, Jun Zhou, Daniel Hartl, Julien Ayroles. OEB, Harvard University, Cambridge, MA.

52 - 12:15
Adaptation to hypoxia in experimentally evolved Drosophila melanogaster: convergent and highly polygenic. Aashish R. Jha^1,2, Christopher D. Brown², Dan Zhou³, Gabriel H. Haddad³, Kevin P. White^1,2,4. 1) Human Genetics, The University of Chicago, Chicago, IL; 2) Institute of Genomics and Systems Biology, The University of Chicago, Chicago, IL; 3) Department of Pediatrics, University of California an Diego; 4) Ecology and Evolution, The University of Chicago, Chicago, IL.

Friday, April 5   10:45 AM–12:30 PM

Cell Biology and Signal Transduction II

Co-Moderators: Helen McNeil, Mount Sinai Hospital, Toronto, Canada and Jin Jiang, UTSW, Dallas, Texas

Room: Marriott Ballroom Salon 2, Lobby Level

53 - 10:45
The spatial distribution of tension on E-cadherin in migrating border cells. Danfeng Cai¹, Li He², Jessica Sawyer³, Denise Montell¹. 1) Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD; 2) Department of Genetics, Harvard Medical School, HHMI, Boston, MA; 3) Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC.

54 - 11:00
Real-time analysis of the dynamics of coordinated epithelial plasticity. Lara C. Skwarek, David Bilder. Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA.

55 - 11:15
Robo2 shapes Slit-dependent muscle repulsion by altering the association of Slit to tendon cell surface. Elly Ordan¹, Marko Brankatschk², Frank Schnorrer³, Talila Volk¹. 1) molecular genetics, Weizmann Institute of Science, Rehovot, Israel; 2) Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany; 3) Muscle Dynamics,Max-Planck-Institute for Biochemistry, Munich,Germany.

56 - 11:30
Regulation of Hippo signaling by EGFR-MAPK signaling through Ajuba. Venu Reddy Bommireddy Venkata, Ken Irvine. Waksman Institute, Piscataway, NJ.

57 - 11:45
Src controls tumorigenesis through JNK-dependent regulation of the Hippo pathway. Masato Enomoto¹, Tatsushi Igaki^1,2. 1) Division of Genetics, Kobe University Graduate School of Medicine, Kobe, Japan; 2) PRESTO, Japan Science and Technology Agency (JST), Saitama, Japan.

58 - 12:00
The Hippo Pathway targets the Cdh1/fzr inhibitor Rae1 to regulate mitosis and establish organ size homeostasis. Maryam Jahanshahi¹, Kuangfu Hsiao², Andreas Jenny³, Cathie Pfleger¹. 1) Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY; 2) Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York NY; 3) Department of Molecular and Developmental Biology, Albert Einstein College of Medicine, Bronx NY.

59 - 12:15
dCORL is required for dSmad2 activation of Ecdysone Receptor expression in the Drosophila mushroom body. Stuart J. Newfeld¹, Michael Stinchfield¹, Kazumichi Shimizu², Mayu Arase³, Janine Quijano¹, Tetsuro Watabe³, Kohei Miyazono³, Norma T. Takaesu¹. 1) Sch Life Sci, Arizona State Univ, Tempe, AZ; 2) Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113-0032, Japan; 3) Department of Molecular Pathology, University of Tokyo, Tokyo 113-0033, Japan.

Friday, April 5   10:45 AM–12:30 PM

RNA Biology

Co-Moderators: Eric Lai, Memorial Sloan Kettering, New York and Halyna Shcherbatta, Max Plank Institute, Gottingen, Germany

Room: Marriott Ballroom Salon 3, Lobby Level

60 - 10:45
Steroid-induced microRNA let-7 acts as a spatio-temporal code for neuronal cell fate in the developing Drosophila brain. Mariya M. Kucherenko, Halyna R. Shcherbata. MPRG of Gene expression and signaling, Max Planck Institute for biophysical chemistry, Goettingen, Germany.

61 - 11:00
miRNome analyses reveal K box miRNAs function in mediating class specific dendrite morphogenesis. Srividya Chandramouli Iyer¹, Myurajan Rubaharan¹, Ramakrishna Meduri¹, Shruthi Sivakumar¹, Francis Aguisanda¹, Suhas Gondi¹, Atit Patel¹, Eswar P. R. Iyer¹, Diane Bortolamiol-Becet², Eric C. Lai², Daniel N. Cox¹. 1) School of Systems Biology, Krasnow Inst. Adv. Study, George Mason University, Fairfax, VA; 2) Sloan-Kettering Institute, Dept. Developmental Biology, New York, NY.

62 - 11:15
Piwi Is Required in Multiple Cell Types to Control Germline Stem Cell Lineage Development in the Drosophila Ovary. Xing Ma^1,2. 1) Stowers Institute for Medical Research, Kansas city, MO; 2) Department of Anatomy and Cell Biology, University of Kansas, Medical Center.

63 - 11:30
Role of the nuclear pore in piRNA biogenesis and speciation. Swapnil Parhad¹, Jie Wang², Zhiping Weng², William Theurkauf¹. 1) Program in Molecular Medicine,Univ Massachusetts Med Sch, Worcester, MA; 2) Program in Bioinformatics and Integrative Biology, Univ Massachusetts Med Sch, Worcester, MA.

64 - 11:45
Modeling Spinal Muscular Atrophy point mutations in Drosophila melanogaster. A. Gregory Matera, Kavita Praveen, Ying Wen. Department of Biology, Univ of North Carolina, Chapel Hill, NC.

65 - 12:00
A conserved RNA processing pathway coordinates striated muscle development. Aaron N. Johnson^1,3, Mayssa M. Mokalled², Kenneth D. Poss², Eric N. Olson³. 1) Department of Integrative Biology, University of Colorado Denver, Denver, CO; 2) Department of Cell Biology and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC; 3) Department of Molecular Biology, UT Southwestern Medical Center at Dallas, Dallas, TX.

66 - 12:15
Identification of a novel splicing factor required for proper myotendenous junction formation and maintenance in Drosophila. Kate M. Rochlin^1,2, Mary Baylies¹. 1) Dept Dev Biol, Sloan-Kettering Inst, New York, NY; 2) Weill Cornell Biomedical University New York, NY.

Friday, April 5   4:30 PM–6:30 PM

Neurophysiology and Behavior

Co-Moderators: Michael Reiser, Janelia Farms Research Campus, Arlington, Virginia and Mala Murthy, Princeton University, New Jersey

Room: Marriott Ballroom Salon 1, Lobby Level

67 - 4:30
Synaptic endosomes as sorting stations for synaptic vesicle proteins. Valerie Uytterhoeven, Ine Maes, Sabine Kuenen, Jaroslaw Kasprowicz, Katarzyna Miskiewicz, Patrik Verstreken. Center for human Genetics, KU Leuven, Center for the Biology of Disease, VIB, Leuven, Vlaams-Brabant, Belgium.

68 - 4:45
Cold avoidance and cold sensing in the Drosophila larva. Mason Klein^1,2, Ashley Vonner^1,3, Marc Gershow^1,2, Elizabeth Kane^1,3, Bruno Afonso¹, Paul Garrity⁴, Aravinthan Samuel^1,2. 1) Center for Brain Science, Harvard University, Cambridge, MA; 2) Department of Physics, Harvard University, Cambridge, MA; 3) Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA; 4) Department of Biology, Brandeis University, Waltham, MA.

69 - 5:00
Drosophila taste receptors reveal combinatorial and cross-modality functions. Erica Freeman¹, Alice French², Zev Wisotsky³, Frédéric Marion-Poll^2,4, Anupama Dahanukar^1,3,5. 1) Bioengineering Graduate Program, University of California, Riverside, CA; 2) INRA, Physiologie de l'Insecte: Signalisation et Communication, Versailles, France; 3) Neuroscience Program, University of California, Riverside, CA; 4) AgroParisTech, Départment Sciences de la Vie et Santé, Paris Cedex 05, France; 5) Department of Entomology, University of California, Riverside, CA.

70 - 5:15
Evolved changes in pheromone production underlie differences in larval social behaviors between closely related Drosophilids. Joshua D. Mast, David L. Stern. Janelia Farm Research Campus, HHMI, Ashburn, VA.

71 - 5:30
A sexually dimorphic flight muscle functions in the generation of Drosophila male courtship song. Troy Shirangi, David Stern, James Truman. JFRC/HHMI, Ashburn, VA.

72 - 5:45
Drosophila melanogaster flies communicate using substrate-borne vibrations during courtship. Caroline C. G. Fabre¹, Berthold Hedwig², Graham Conduit², Peter A. Lawrence², Stephen Goodwin³, José Casal². 1) Department of Zoology, Cambridge University and Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, United Kingdom; 2) Department of Zoology, Cambridge University, Cambridge, United Kingdom; 3) Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, United Kingdom.

73 - 6:00
Juvenile hormone acts through Methoprene tolerant to modulate female receptivity and sex pheromones in Drosophila melanogaster . Julide Bilen¹, Jade Atallah², Reza Azanchi¹, Joel Levine², Lynn Riddiford¹. 1) Janelia Farm Research Campus HHMI, Ashburn, VA; 2) Department of Biology, University of Toronto, Ontario, Canada.

74 - 6:15
The neurobiological basis of personality in flies. Benjamin L. de Bivort^1,2,3, Jamey S. Kain¹, Sean M. Buchanan¹, Julien Ayroles³, Chelsea Jenney¹, Sarah Zhang¹. 1) Rowland Institute, Harvard University, Cambridge, MA; 2) Center for Brain Science, Harvard University, Cambridge, MA; 3) Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA.

Friday, April 5   4:30 PM–6:30 PM

Cell Biology and Cytoskeleton

Co-Moderators: Susan Parkhurst, Fred Hutchinson Cancer Center, Seattle, Washington and Lynn Cooley, Yale, New Haven, Connecticut

Room: Marriott Ballroom Salon 2, Lobby Level

75 - 4:30
Multi-parametric analysis of CLASP-interacting protein functions during interphase microtubule dynamics. Jennifer B. Long¹, Maria Bagonis¹, Laura Anne Lowery¹, Haeryun Lee^1,2, Gaudenz Danuser¹, David Van Vactor¹. 1) Cell Biology, Harvard Medical School, Boston, MA; 2) Pohang University of Science and Technology, Pohang, Gyungbuk, KOREA.

76 - 4:45
Dynamic myosin phosphorylation is required for pulsed contractions during apical constriction. Claudia G. Vásquez, Adam C. Martin. Biology, Massachusetts Institute of Technology, Cambridge, MA.

77 - 5:00
Regulation of epithelial morphogenesis by overlapping expression of Folded gastrulation (Fog), and its receptor, Mist. Alyssa J. Manning, Kimberly Peters, Stephen L. Rogers. Biology Department, UNC-Chapel Hill, Chapel Hill, NC.

78 - 5:15
Misshapen regulates integrin levels to promote epithelial motility and planar polarity in Drosophila. Lindsay K. Lewellyn, Maureen Cetera, Sally Horne-Badovinac. Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL.

79 - 5:30
Role of Calcium and Rho family small GTPases in Single Cell Wound Repair. Maria Teresa Abreu-Blanco, Susan M. Parkhurst. Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

80 - 5:45
Branching Out: Genetic analysis of branch outgrowth in terminal cells. Tiffani A. Jones, Mark M. Metzstein. Human Gen, Univ Utah, Salt Lake City, UT.

81 - 6:00
Live imaging of Drosophila neuroblast delamination reveals two stages with differential cytoskeletal dynamics. Yan Yan^1,2, Chris Doe². 1) Division of Life Science, HKUST, Hong Kong, Kowloon, Hong Kong; 2) Institute of Neuroscience/HHMI, University of Oregon, Eugene, OR.

82 - 6:15
Alp/Enigma family proteins cooperate in Z-disc formation and myofibril assembly. Frieder Schoeck, Stefan Czerniecki, Kuo An Liao, Anja Katzemich. Dept Biol, McGill Univ, Montreal, PQ, Canada.

Friday, April 5   4:30 PM–6:30 PM

Chromatin and Epigenetics

Co-Moderators: Jerry Workman, Stowers Institute, Kansas City, Missouri and Andrew Dingwall, Loyola University, Chicago, Illinois

Room: Marriott Ballroom Salon 3, Lobby Level

83 - 4:30
UpSET modulates open chromatin features at active transcribed genes. Hector Rincon-Arano, Jessica Halow, Jeffrey Delrow, Susan Parkhurst, Mark Groudine. Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

84 - 4:45
Sorted cell ChIP-seq shows the molecular organization of Polycomb-repressed chromatin in the bithorax complex. Sarah K. Bowman¹, Aimee M. Deaton¹, Heber Domingues², Welcome Bender², Robert E. Kingston¹. 1) Dept. of Molecular Biology, Massachusetts General Hospital, and Dept. of Genetics, Harvard Medical School, Boston, MA; 2) Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.

85 - 5:00
Genome-wide Analysis of the Binding Sites of the JIL-1 H3S10 Kinase and its Contribution to Modulation of Gene Expression. Kristen M. Johansen¹, Weili Cai¹, Chao Wang¹, Lu Shen¹, Yeran Li¹, Sanzhen Liu², Changfu Yao¹, Xiaomin Bao¹, Patrick S. Schnable^2,3, Jack Girton¹, Jørgen Johansen¹. 1) Biochem, Biophys & Molec Biol, Iowa State Univ, Ames, IA; 2) Agronomy, Iowa State Univ, Ames, IA; 3) Data2Bio LLC, Ames, IA.

86 - 5:15
Piwi is linked to heterochromatin formation in the embryo of Drosophila melanogaster. Tingting Gu, Sarah Elgin. Department of Biology, Washington University in St Louis, St Louis, MO.

87 - 5:30
Epigenetic regulation of olfactory receptor gene choice. Sarah Perry¹, Choon Kiat Sim², Sana Tharadra¹, Anand Ray¹. 1) Entomology, UC Riverside, Riverside, CA; 2) Department of Genetics, Stanford University, Stanford, CA.

88 - 5:45
The chromatin configurations of Polycomb Response Elements (PREs) define epigenetic states. Kami Ahmad¹, Guillermo Orsi¹, Steven Henikoff², Jorja Henikoff². 1) Dept BCMP, Harvard Medical Sch, Boston, MA; 2) FHCRC, Seattle, WA.

89 - 6:00
Stuxnet Regulates PRC1-mediated Epigenetic Silencing by Promoting Ubiquitinated Polycomb Protein for Degradation. Juan Du¹, Junzheng Zhang¹, Feng Tie², Ying Su¹, Peter Harte², Alan Jian Zhu¹. 1) Department of Cellular & Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; 2) Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH.

90 - 6:15
Telomere protection in Drosophila: functional analysis of the terminin complex. Grazia D. Raffa, Emanuela Micheli, Fiammetta Verni, Domenico Raimondo, Alessandro Cicconi, Laura Ciapponi, Giovanni Cenci, Stefano Cacchione, Maurizio Gatti. Biology and Biotechnology, Sapienza Universita' di Roma, Rome, Italy.

Saturday, April 6   8:30 AM–10:15 AM

Drosophila Models of Human Disease I

Co-Moderators: Ross Cagan, Mount Sinai School of Medicine, New York and Leo Pallanck, University of Washington, Seattle

Room: Marriott Ballroom Salon 1, Lobby Level

91 - 8:30
Mannitol - a BBB disrupter is also a potent α-synuclein aggregation inhibitro for treating Parkinson's disease. Daniel Segal^1,2, Ronit Shaltiel-Karyo¹, Moran Frenkel-Pinter¹, Edward Rockenstein³, Christina Patrick³, Michal Levy-Sakin¹, Nirit Egoz-Matia¹, Eliezer Masliah³, Ehud Gazit¹. 1) Department of Molecular Microbiol & Biotech, Tel Aviv University, Tel Aviv 69978, Israel; 2) Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel; 3) Department of Neurosciences, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

92 - 8:45
Bioinformatics-driven approaches to building new fly models of human disease. Stephanie E. Mohr¹, Yanhui Hu¹, Ian Flockhart¹, Juliane Schneider², Charles Roesel^1,3, Lizabeth Perkins¹, Norbert Perrimon^1,4. 1) Dept Gen, Harvard Med Sch, Boston, MA; 2) Countway Medical Library, Harvard Med Sch, Boston, MA; 3) Grad Program in Bioinformatics, Northeastern University, Boston, MA; 4) Howard Hughes Medical Institute, Boston, MA.

93 - 9:00
Early mitochondrial dysfunction leads to oxidative stress in a drosophila model of TPI deficiency. Stacy Hrizo^1,2, Isaac J. Fisher¹, Bartholomew P. Roland², Daniel R. Long¹, Joshua A. Hutton¹, Zhaohui Liu², Michael J. Palladino². 1) Biology, Slippery Rock University, Slippery Rock, PA; 2) Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

94 - 9:15
Signaling pathways involved in 1-octen-3-ol mediated neurotoxicity in Drosophila melanogaster: Implication in Parkinson’s Disease. Arati A. Inamdar, Joan W. Bennett. Department of Plant Biology and Pathology, Rutgers, The State University of New Jersey, New Brunswick, NJ.

95 - 9:30
4-aminoquinoline analogs rescue neurotoxicity in a Drosophila model of ALS based on TDP-43. Alyssa Coyne¹, Marilyn Roy², Ivy Lin², Joel Cassel⁴, Mark McDonnell⁴, Allen Reitz⁴, Daniela Zarnescu^2,3. 1) Department of Neuroscience, University of Arizona, Tucson, AZ 85721, USA; 2) Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA; 3) Department of Neurology, University of Arizona, Tucson, AZ 85721, USA; 4) Biopharma, LLC, Pennsylvania Biotechnology Center, Doyleston, PA 18902, USA.

96 - 9:45
A Drosophila melanogaster model identifies a critical role for zinc in initiating urinary stone formation. Thomas Chi¹, Man Su Kim², Nichole Bond¹, Sven Lang³, Joe Miller¹, Gulinuer Muteliefu³, Katja Bruckner¹, Arnie Kahn³, Marshall Stoller¹, Pankaj Kapahi³. 1) UCSF, San Francisco, CA; 2) College of Pharmacy, Inje University, Republic of Korea; 3) Buck Institute for Research on Aging, Novato, CA.

97 - 10:00
Inhibition of JNK/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer’s disease model. Se Min Bang, Yoon Ki Hong, Soojin Lee, Kyoung Sang Cho. Biological sciences, Kunkok university, Seoul, Seoul, South Korea.

Saturday, April 6   8:30 AM–10:15 AM

Regulation of Gene Expression I

Co-Moderators: Erica Larschan, Brown University, Providence, Rhode Island and Angela Stathopoulos, CalTech, Pasadena, California

Room: Marriott Ballroom Salon 2, Lobby Level

98 - 8:30
Expression pattern analysis of 6,300 genomic fragments for cis-regulatory activity in the imaginal discs of Drosophila Melanogater. Aurélie Jory¹, Carlos Estella^1,3, Matt W. Giorgianni^1,4, Matthew Slattery^1,5, Todd R. Laverty², Gerald M. Rubin², Richard S. Mann¹. 1) Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, 701 W. 168th Street, HHSC 1104, New York, NY 10032, USA; 2) Janelia Farms Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA; 3) Present address: Departamento de Biología Molecular, and Centro de Biología Molecular ‘‘Severo Ochoa,’’ Universidad Autónoma de Madrid, Madrid, Spain; 4) Present address: R.M. Bock Laboratories, University of Wisconsin-Madison, 1525 Linden Drive, Madison, WI 53706, USA; 5) Present address: Institute for Genomics and Systems Biology, University of Chicago, 900 E. 57th St. KCBD 10115, Chicago, IL 60637, USA.

99 - 8:45
DNA regulatory element usage is driven largely by developmental stage, even within distinct cell lineages. Daniel J. McKay¹, Jason D. Lieb^1,2. 1) Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC; 2) Carolina Center for Genome Sciences.

100 - 9:00
Differential regulation of sloppy-paired-1 transcription initiation and elongation by Runt and Even-skipped during Drosophila segmentation. Kimberly Bell^1,3, Saiyu Hang^2,3, J. Peter Gergen³. 1) Graduate Program in Genetics; 2) Graduate Program in Biochemistry and Structural Biology; 3) Department of Biochemistry and Cell Biology and the Center for Developmental Genetics Stony Brook University, Stony Brook, NY 11794-5215.

101 - 9:15
Robust Hox-Mediated Transcriptional Regulation Utilizes a Combination of Flexible Binding Site Composition and Rigid Grammar. Juli Uhl, Lisa Gutzwiller, Arif Ghasletwala, Brian Gebelein. Developmental Biology, Cincinnati Children's Hospital, Cincinnati, OH.

102 - 9:30
Autoregulation controls temporal progression of gene expression during development. Leslie A. Dunipace, Angelike Stathopoulos. Biology, California Institute of Technology, Pasadena, CA.

103 - 9:45
Tissue-specificity of Drosophila Developmental Gene Regulatory Networks. Matthew Slattery¹, Roumen Voutev², Rebecca Spokony¹, Lijia Ma¹, Richard Mann², Kevin White¹. 1) Institute for Genomics and Systems Biology, University of Chicago, Chicago, IL; 2) Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY.

104 - 10:00
Regulation of rhodopsins: Single nucleotides are critical for photoreceptor subtype-specific expression. Jens Rister, Claude Desplan. New York University, Department of Biology, 100 Washington Square East, New York, NY.

Saturday, April 6   8:30 AM–10:15 AM

Stem Cells

Co-Moderators: Katja Bruckner, University of California, San Francisco and Allan Spradling, Carnegie Institute, Baltimore, Maryland

Room: Marriott Ballroom Salon 3, Lobby Level

105 - 8:30
Chinmo prevents male-to-female sex transformation of somatic stem cells in the adult Drosophila testis. Qing Ma¹, Matthew Wawersik², Erika Matunis¹. 1) Cell Biology Dept, The Johns Hopkins Sch Med, Baltimore, MD; 2) Biology Dept, The Col of William & Mary, Williamsburg, VA.

106 - 8:45
Identification of genes modifying epigenetic plasticity during follicle cell differentiation. Ming-Chia Lee¹, Andrew Skora², Allan Spradling¹. 1) Department of Embryology, Carnegie Institution of Washington, Baltimore, MD; 2) Ludwig Center for Cancer Genomics and Therapeutics, Johns Hopkins School of Medicine, Baltimore, MD.

107 - 9:00
The Hox gene Abd-B controls stem cell niche function in the Drosophila testis. Fani Papagiannouli¹, Lisa Schardt², Nati Ha¹, Janina-Jacqueline Ander¹, Ingrid Lohmann¹. 1) Developmental Biology, Centre for Organismal Studies (COS), Heidelberg, Germany; 2) Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.

108 - 9:15
Niche appropriation by Drosophila intestinal stem cell tumors. Parthive H. Patel^1,2, Devanjali Dutta², Bruce A. Edgar^1,2. 1) Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA USA; 2) German Cancer Research Center (DKFZ) and Center for Molecular Biology Heidelberg (ZMBH) Alliance, Heidelberg, Germany.

109 - 9:30
Gastric Stem Cells Maintain the Adult Drosophila Stomach. Craig A. Micchelli, Marie Strand. Developmental Biology, Washington University School of Medicine, St. Louis, MO.

110 - 9:45
Neuron-produced Activinβ supports hematopoiesis in the Drosophila larva. Kalpana Makhijani², Brandy Alexander², Sophia Petraki², Michael O'Connor⁴, Katja Brückner^1,2,3. 1) Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research; 2) Department of Cell and Tissue Biology; 3) Department of Anatomy, University of California San Francisco, San Francisco, CA; 4) Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN.

111 - 10:00
A genome-wide RNAi screen for Neuroblast cell cycle exit in Drosophila. Catarina Homem, Juergen Knoblich. IMBA, Vienna, Austria.

Saturday, April 6   10:45 AM–12:30 PM

Drosophila Models of Human Disease II

Co-Moderators: Ross Cagan, Mount Sinai School of Medicine, New York and Leo Pallanck, University of Washington, Seattle

Room: Marriott Ballroom Salon 1, Lobby Level

112 - 10:45
Drug screening on a new Drosophila cardiac model of Friedreich Ataxia. Veronique Monnier, Hervé Tricoire. BFA Unit, University Paris Diderot, 75205 Paris Cedex 13, France.

113 - 11:00
Rescue of insulin signaling misregulation in a fly model of fragile x syndrome. Rachel E. Monyak¹, Danielle Emerson¹, Yan Wang¹, Xiangzhong Zheng², Brian Schoenfeld³, Sean McBride¹, Amita Sehgal², Thomas Jongens¹. 1) Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia, PA; 2) Howard Hughes Medical Institute and Department of Neuroscience University of Pennsylvania Perelman School of Medicine Philadelphia, PA; 3) Section of Molecular Cardiology Departments of Medicine and Molecular Pharmacology Albert Einstein College of Medicine Bronx, NY.

114 - 11:15
Sphingosine 1-phosphate mediated suppression of dystrophic muscle wasting in Drosophila and mice. Mario Pantoja¹, Karin A. Fischer¹, Nicholas Ieronimakis², Timothy L. Dosey¹, Junlin Qi¹, Aislinn Hayes², Morayma Reyes^2,3, Hannele Ruohola-Baker¹. 1) Dept Biochem, Univ Washington, Seattle, WA; 2) Dept Pathology; 3) Dept Labortory Medicine.

115 - 11:30
A kinome-wide RNAi screen in Drosophila glia reveals new kinases that mediate cell proliferation and survival in human glioblastoma. Renee Read^1,2, Tim Fenton³, German Gomez³, Jill Wykosky³, Scott Vandenberg⁴, Ivan Babic³, Akio Iwanami⁵, Huijun Yang³, Webster Cavenee³, Paul Mischel³, Frank Furnari³, John Thomas². 1) Department of Pharmacology, Emory University School of Medicine, Atlanta, GA; 2) The Salk Institute for Biological Studies, Molecular Neurobiology Laboratory, La Jolla, CA; 3) Ludwig Institute for Cancer Research, University of California - San Diego, La Jolla, CA; 4) Department of Pathology, University of California - San Diego, La Jolla, CA; 5) Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.

116 - 11:45
Functional characterisation of human synapse genes expressed in the Drosophila brain, applications in drug screening. Matt B. Mahoney, Lysimachos Zografos, R. Wayne Davies, J. Douglas Armstrong. Brainwave Discovery, LTD, Ardshiel, Main Street, Gartmore, FK8 3RJ, United Kingdom.

117 - 12:00
Renal proximal tubule receptors Cubilin and Amnionless mediate protein reabsorption in Drosophila nephrocytes. Fujian Zhang¹, Ying Zhao¹, Yufang Chao¹, Katherine Muir¹, Zhe Han^1,2. 1) Department of Internal Medicine, University of Michigan, Ann Arbor, MI; 2) Department of Cell and Developmental Biology.

118 - 12:15
SMN is required for RNA splicing in sensory-motor circuits. Brian McCabe^1,2, Francesco Lotti¹, Erin Beck^1,2, Ben Choi^1,2, George Mentis¹, Christine Beattie³, Livio Pellizzoni¹, Wendy Imlach^1,2. 1) Pathology & Cell Biology, Columbia University, New York, NY; 2) Neuroscience, Columbia University, New York, NY; 3) Neuroscience, The Ohio State University, Columbus, OH.

Saturday, April 6   10:45 AM–12:30 PM

Regulation of Gene Expression II

Co-Moderators: Erica Larschan, Brown University, Providence, Rhode Island and Angelika Stathopoulos, CalTech, Pasadena, California

Room: Marriott Ballroom Salon 2, Lobby Level

119 - 10:45
Widespread and distinct sequence signatures of combinatorial transcriptional regulation. M. Kazemian¹, H. Pham², M. Brodsky², S. Sinha¹. 1) U of Illinois, Urbana, IL; 2) UMASS Med School, Worcester, MA.

120 - 11:00
Synergistic interactions between MSL complex and the CLAMP protein regulate Drosophila dosage compensation. Marcela Soruco¹, Jessica Chery¹, Eric Bishop^2,7, Trevor Siggers³, Michael Tolstorukov^2,3, Alexander Leydon¹, Arthur Sugden¹, Karen Goebel¹, Jessica Feng¹, Peng Xia¹, Anastasia Vedenko³, Martha Bulyk^3,4,5, Peter Park^2,3,6, Erica Larschan¹. 1) Department of Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, RI 02912; 2) Center for Biomedical Informatics, Harvard Medical School, Boston, MA 02115; 3) Division of Genetics, Department of Medicine, Brigham & Women’s Hospital and Harvard Medical School, Boston, MA 02115; 4) Department of Pathology, Brigham & Women’s Hospital and Harvard Medical School, Boston, MA, 02115; 5) Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115; 6) Children’s Hospital Informatics Program, Boston, MA 02115; 7) Bioinformatics Graduate Program, Boston University, Boston, MA 02215.

121 - 11:15
Akirin: a novel link between Twist transcription factor activity and Brahma chromatin remodeling complexes during embryogenesis. Scott J. Nowak¹, Hitoshi Aihara³, Katie Gonzalez², Yutaka Nibu³, Mary K. Baylies². 1) Dept. of Biology and Physics, Kennesaw State University, Kennesaw, GA 30144; 2) Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065; 3) Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10065.

122 - 11:30
Zelda's role in Drosophila zygotic genome activation. Yujia Sun¹, Sun Melody Foo¹, Chung-Yi Nien¹, Hsiao-Yun Liu¹, Kai Chen², Kevin O'Brien¹, Amruta Tamhane¹, Julia Zeitlinger², Christine Rushlow¹. 1) Department of Biology, New York University, New York, NY 10003; 2) Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110.

123 - 11:45
Analysis of evolution within the bHLH transcription factor family based on a complete set of DNA binding interaction specificities. Hannah Pham, Jianhong Ou, Scot Wolfe, Michael Brodsky. Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA.

124 - 12:00
Transcription Start Site Turnover in Drosophila using CAGE. Bradley J. Main, Hyosik Jang, Andrew Smith, Sergey Nuzhdin. MCB, Univ Southern California, Los Angeles, CA.

125 - 12:15
Role of regulatory small peptides in the control of gene expression. Francois Payre^1,2, Emilie Benrabah^1,2, Jennifer Zanet^1,2, Serge Plaza^1,2. 1) Center for Developmental Biology, University of Toulouse,Toulouse, France; 2) CNRS, UMR5547, Toulouse France.

Saturday, April 6   10:45 AM–12:30 PM

Pattern Formation

Co-Moderators: Ruth Lehman, Skirball, New York and Francois Payre, Universite de Toulouse, France

Room: Marriott Ballroom Salon 3, Lobby Level

126 - 10:45
Bonus is maternally required for Dorsal nuclear translocation and zygotically for Dpp responsiveness in dorsal-ventral axis formation. Janine Quijano, Michael Stinchfield, Stuart Newfeld. School of Life Sciences, Arizona State Univ, Tempe, AZ.

127 - 11:00
Nanobodies as novel tools to study morphogen gradient formation in vivo. Stefan Harmansa, Markus Affolter, Emmanuel Caussinus. Biozentrum, Universität Basel, Basel, Switzerland.

128 - 11:15
The dynamics of patterning in the Drosophila wing imaginal discs change under different environmental and internal cues. Marisa Oliveira¹, Alexander Shingleton², Christen Mirth¹. 1) Instituto Gulbenkian de Ciência, Oeiras, Oeiras, Portugal; 2) Dept. of Zoology, Michigan State University.

129 - 11:30
Collapse of compartment boundaries and induced identity changes after massive damage in the imaginal discs of Drosophila. Salvador C. Herrera, Ginés Morata. Centro de Biología Molecular (CSIC-UAM), Madrid, Madrid, Spain.

130 - 11:45
Interchromosomal communication coordinates an intrinsically stochastic expression decision between alleles. Robert J. Johnston, Claude Desplan. Biology, New York University, New York, NY.

131 - 12:00
Robustness of cell type identity in Drosophila embryos depleted for bicoid. Max V. Staller¹, Meghan D. Bragdon¹, Zeba B. Wunderlich¹, Norbert Perrimon², Angela H. DePace¹. 1) Department of Systems Biology, Harvard Medical School, Boston, MA; 2) Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA.

132 - 12:15
BMP signaling likely had an ancestral role in providing global embryonic dorsal-ventral polarity in insects. Jeremy A. Lynch^1,2, Orhan Özüak², Thomas Buchta², Siegfried Roth². 1) Molecular, Cell, and Developmental Biology, University of Illinois at Chicago, Chicago, IL; 2) Institute for Developmental Biology, University of Cologne, Cologne, Germany.

Saturday, April 6   4:00 PM–6:00 PM

Cell Cycle and Cell Death

Co-Moderators: Hyung Don Ryoo, New York University and Brian Calvi, Indiana University, Bloomington

Room: Marriott Ballroom Salon 1, Lobby Level

133 - 4:00
A novel role of Drosophila P/Q type voltage gated calcium channel subunits in autophagy. Upasana Gala¹, Chao Tong^2,3, Manish Jaiswal², Hector Sandoval², Shinya Yamamoto¹, Vafa Bayat¹, Bo Xiong¹, Ke Zhang⁴, Wu-Lin Charng¹, Lita Duraine⁵, Kartik Venkatachalam⁶, Hugo Bellen^1,2,5. 1) Program in Developmental Biology, BCM; 2) Department of Human and Molecular Genetics, BCM; 3) Department of Molecular Biology, Zhejiang University; 4) Structural & Computational Biology & Molecular Biophysics Program, BCM; 5) Howard Hughes Medical Institute; 6) Department of Integrative Pharmacology, UTHSC.

134 - 4:15
Zonda: A novel gene involved in autophagy and growth control. Mariana Melani¹, Maria Julieta Acevedo¹, Joel Perez Perri¹, Nuria Magdalena Romero², Pablo Wappner¹. 1) Fundacion Instituto Leloir, Buenos Aires, Buenos Aires, Argentina; 2) Institute of Developmental Biology and Cancer, Nice, France.

135 - 4:30
Ino80 is required for ecdysone-dependent regulation of PI3K/Akt signaling during Drosophila development. Sarah Neuman, Robert Ihry, Arash Bashirullah. University of Wisconsin-Madison, Madison, WI.

136 - 4:45
Necrotic cell death is mediated by a specific chromatin-modifying pathway in fly and mammals. Kai Liu¹, Yuhong Li¹, Lianggong Ding¹, Hui Yang¹, Chunyue Zhao¹, Hermann Steller², Lei Liu¹. 1) State Key Lab of Biomembrane and Membrane Biotechnology, School of Life Sciences, Peking University, Beijing, China; 2) Strang Laboratory of Apoptosis and Cancer Biology, Howard Hughes Medical Institute, The Rockefeller University, NY.

137 - 5:00
The endocycle promotes aneuploidy at both ends of the spindle. Donald T. Fox^1,2, Ruth Montague¹, Kevin Schoenfelder¹, Benjamin Stormo², Sarah Paramore¹. 1) Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC; 2) Department of Cell Biology, Duke University Medical Center, Durham, NC.

138 - 5:15
Cell cycle remodeling is sufficient to repress apoptosis. Suozhi Qi, Christiane Hassel, Brian R. Calvi. Indiana University, Bloomington, IN.

139 - 5:30
The Molecular Chaperone Hsp90 is Required for Cell Cycle Exit. Jennifer L. Bandura^1,2, Huaqi Jiang^1,3, Derek W. Nickerson¹, Bruce A. Edgar^1,2. 1) Fred Hutchinson Cancer Research Center, 1100 Fairview Ave., Seattle, WA 98109, USA; 2) German Cancer Research Center (DKFZ) - Center for Molecular Biology Heidelberg (ZMBH) Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany; 3) Current address: UT Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd., Dallas, TX 75235, USA.

140 - 5:45
Phosphorylation of Caprin by Chk1(Grapes) May Control the Cell Cycle at the Mid-Blastula Transition. Helen X. Chen^1,3, Ophelia Papoulas^2,3, Paul Macdonald^1,3. 1) Section of Molecular Cell and Developmental Biology; 2) Center for Systems and Synthetic Biology; 3) The Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712.

Saturday, April 6   4:00 PM–6:00 PM

Gametogenesis and Organogenesis

Co-Moderators: Cordula Schulz, University of Geogia, Athens and Wu-Min Deng, Florida State University, Ft. Lauderdale

Room: Marriott Ballroom Salon 2, Lobby Level

141 - 4:00
Ecdysone Signaling Antagonizes EGF Signaling in Germline-Cyst Cell Interactions of Drosophila melanogaster Testes. Ricky W. Zoller, Cordula Schulz. Cellular Biology, University of Georgia, Athens, GA.

142 - 4:15
Localization and functional analysis of Nmd and CG4701 AAA proteins in mitochondrial and microtubule dynamics in Drosophila spermatogenesis. Bethany L. Wagner, Lindsay A. Regruto, Melissa Lorenzo, Jessica Gerard, Sarah C. Pyfrom, Karen G. Hales. Department of Biology, Davidson College, Davidson, NC.

143 - 4:30
NPR2/3 define a novel nutrient stress pathway in the Drosophila ovary. Youheng Wei, John Reich, Weili Cai, Tanveer Akbar, Kuikwon Kim, Mary Lilly. Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.

144 - 4:45
Tramtrack69 regulates epithelial tube expansion in the Drosophila ovary through Paxillin, Dynamin, and the homeobox protein Mirror. Nathaniel Peters, Celeste Berg. Dept of Genome Sciences/MCB Program, University of Washington, Seattle, WA.

145 - 5:00
Ovulation requires female reproductive tract secretions controlled by NR5a-family nuclear hormone receptors. Jianjun Sun, Allan Spradling. HHMI Laboratory, Department of Embyology, Carnegie Institution for Science, Baltimore, MD.

146 - 5:15
Using transcriptome and phosphoproteome profiling to identify genes that regulate the egg-to-embryo transition in D. melanogaster. Caroline V. Sartain, Amber R. Krauchunas, Jun Cui, Vanessa L. Horner, Jeffrey A. Pleiss, Mariana F. Wolfner. Dept Molec Biol & Gen, Cornell Univ, Ithaca, NY.

147 - 5:30
Intercellular Protein Equilibration through Somatic Ring Canals. Peter McLean. Genetics, Yale School of Medicine, New Haven, CT.

148 - 5:45
A non-canonical role for Yorkie and the Salvador/Warts/Hippo pathway in tracheal tube-size regulation. Renée M. Robbins, Samantha C. Gbur, Greg J. Beitel. Molecular Biosciences, Northwestern Univ, Evanston, IL.

Saturday, April 6   4:00 PM–6:00 PM

Neural Development

Co-Moderators: Wes Grueber, Columbia University, New York and Ehud Isacoff, University of California, Berkeley

Room: Marriott Ballroom Salon 3, Lobby Level

149 - 4:00
Mutual inhibition among postmitotic neurons regulates robustness of brain wiring. Marion G. Langen^1,2,3, Marta Koch^1,2, Jiekun Yan^1,2, Natalie de Geest^1,2, Marie-Luise Erfurt^4,5, Barret D. Pfeiffer⁶, Dietmar Schmucker^4,5, Yves Moreau⁷, Bassem A. Hassan^1,2,3,4. 1) VIB Center for Biology of Disease, VIB, 3000 Leuven, Belgium; 2) Center for Human Genetics, University of Leuven School of Medicine, 3000 Leuven, Belgium; 3) Doctoral Program in Molecular and Cognitive Neuroscience, Doctoral School of Biomedical Sciences, University of Leuven, 3000 Leuven, Belgium; 4) Vesalius Research Center, VIB, 3000, Leuven, Belgium; 5) Department of Oncology, University of Leuven School of Medicine, 3000 Leuven, Belgium; 6) Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA; 7) Bioinformatics Group, Department of Electrical Engineering, University of Leuven, 3000 Leuven, Belgium.

150 - 4:15
Drosophila epidermal cells function as phagocytes to clear degenerated dendrites during dendrite pruning. Chun Han, Yuanquan Song, Denan Wang, Lily Jan, Yuh-Nung Jan. Howard Hughes Medical Institute, Departments of Physiology, Biochemistry, and Biophysics, Univ California, San Francisco, San Francisco, CA.

151 - 4:30
Control of cell proliferation in the embryonic CNS by Temporal, Hox and Notch cues. Stefan Thor. Dept Clinical and Exp Medicine, Linkoping Univ, Linkoping, OG, Sweden.

152 - 4:45
Hippo-dependent cell fate specification is antagonized by multiple regulatory modules. Baotong Xie¹, David Terrell^1,2,3, Mark Charlton-Perkins^1,2, Brian Gebelein^2,4, Tiffany Cook^1,2,4. 1) Division of Pediatric Ophthalmology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA; 2) Molecular and Developmental Biology Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA; 3) Physician Scientist Training Program, University of Cincinnati, Cincinnati, OH 45229, USA; 4) Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

153 - 5:00
Adult neurogenesis in Drosophila. Eduardo Moreno, Ismael Hernandez-Fernandez, Christa Rhiner. University of Bern, Bern, Switzerland.

154 - 5:15
3D mapping of the adult Drosophila brain: Towards a comprehensive digital atlas of secondary lineages. Darren C. C. Wong, Jennifer K. Lovick, Kathy Ngo, Jaison Omoto, Joseph Nguyen, Volker Hartenstein. MCDB, UCLA, Los Angeles, CA.

155 - 5:30
Development of astrocyte-like and ensheathing glia of the early larva ventral nerve cord. Emilie Peco¹, Sejal Davla¹, Stephanie Stacey¹, Matthias Landgraf², Don van Meyel¹. 1) Centre for Research in Neuroscience, McGill University, Montreal, Qc, Canada; 2) Department of Zoology, University of Cambridge, UK.

156 - 5:45
Activity dependent active zone remodeling in the Drosophila visual system. Atsushi Sugie^1,2, Takashi Suzuki², Gaia Tavosanis¹. 1) DZNE, Bonn, Germany; 2) Titech, Yokohama, Japan.

Sunday, April 7   8:30 AM–12:00 NOON

Plenary Session

Moderator: Hannele Ruohola-Baker, University of Washington, Seattle

Room: Marriott Ballroom Salons 1-3, Lobby Level

Presentations:

8:30 am   Poster Awards. Hannele Ruohola-Baker. University of Washington, Seattle.

8:35 am   Information, Enhancers, and Cell Signaling: a View from the Binding Site. Scott Barolo. University of Michigan Medical School, Ann Arbor, MI.

9:05 am   “The piRNA Pathway: a Small RNA-Based Innate Immune System”. Greg Hannon. HHMI, Cold Spring Harbor Lab, One Bungtown Road, Cold Spring Harbor, NY.

9:35 am   Transcription Factor Network Dynamics in Development. Ilaria Rebay. Ben May Dept, Univ Chicago, Chicago, IL.

10:05 am - Break

10:30 am   The Role of Nuclear Pore Proteins in Developmental Gene Regulation. Martin W. Hetzer. Salk Inst for Biological Studies, La Jolla, CA.

11:00 am   Stem Cells to Synapses: Regulation of Self-Renewal and Differentiation in the Nervous System. Andrea H. Brand. The Gurdon Institute, University of Cambridge, Cambridge, United Kingdom.

11:30 am   Neurodegeneration and Aging: Insight from Drosophila. Nancy M. Bonini. Dept Biol, 306 Leidy Labs, Univ Pennsylvania/HHMI, Philadelphia, PA.

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