Sinbad Fly: A resource for functional variant discovery in Drosophila melanogaster. Kjong-Van Lehmann, Paul Marjoram, Ting Chen. University of Southern California, Los Angeles, CA.

   Functional variant prediction from biological data has become a common complementary approach to many genome wide screens. With the advent of genome wide association studies in model organisms, organism specific prediction of functional variants is desirable. Here we present SInBaD Fly, an extension of our functional variant detection program SInBaD to Drosophila melanogaster. SInBaD Fly is based on using nucleotide sequence conservation across species to distinguish phenotype associated variants from synonymous variants. High accuracies have been achieved and sensitivity/specificity trade-offs are comparable to our human model. A web server is being made available providing predictions for functional variants under different false positive rates in coding regions.