Evolutionary Constraints on DNA Shape. Tevfik H Kitapci, Tianyin Zhou, Remo Rohs, Sergey V. Nuzhdin. University of Southern California, Los Angeles, CA.

   Is DNA Shape, specifically minor groove width, under natural selection? In this study we analyze SNPs coming from full genome data of 66 Drosophila melanogasters. We use a ChIP-seq dataset to annotate transcription factor binding sites. Using high-throughput minor groove width prediction method based on Monte Carlo simulations we analyze SNP frequency distributions. Our preliminary results suggest that there might be selection on DNA minor groove width in transcription factor binding sites.