QTLs associated with female pupal weight on a high fat diet. Kelly Dew-Budd¹, Ronglin Che², Alison Motsinger-Reif², Laura Reed¹. 1) Department of Biological Sciences, University of Alabama, Tuscaloosa, AL; 2) Department of Statistics, North Carolina State University, Raleigh, NC.

   In 2011 the CDC found that greater than one third of Americans were obese. To determine the genotype-by-diet interaction that is contributing to these effects, we used Drosophila melanogaster to model human obesity caused by a high fat diet. Using previously genotyped recombinant inbred DSPR lines, we tested the effect of a high fat diet on female pupal weight compared to larvae raised on the normal laboratory diet. We were able to find multiple quantitative trait loci that corresponded to the change in weight caused by increased fat intake. These QTLs define genomic regions that will be of high interest in future studies to determine the genetic mechanism of phenotypic changes brought on by diet.